Le trifluoroacetyl tripeptide-2 idaduro ti ogbo?

Nipa re:

A peptide jẹ pq ti amino acids ti o ni asopọ nipasẹ awọn ifunmọ peptide.Awọn peptides ni pataki ninu ilana amuaradagba, angiogenesis, imudara sẹẹli, melanogenesis, iṣilọ sẹẹli, ati igbona.Awọn peptides bioactive ti ni lilo pupọ ni ile-iṣẹ ohun ikunra ni awọn ewadun aipẹ.Awọn peptides nilo iwuwo molikula kekere (> 500 Da), lati le dinku itankale peptide laarin awọn ipele epidermal, iduroṣinṣin giga ati solubility.Ni awọn ọdun diẹ, agbegbe ijinle sayensi ti ni idagbasoke kekere ati iduroṣinṣin peptide sintetiki ti o mu iṣelọpọ collagen ṣiṣẹ ati dinku awọn wrinkles oju ati pigmentation.Trifluoroacetyl tripeptide-2 (atẹle: TFA-Val-Try-Val-OH) iṣelọpọ tripeptide, ti a ṣe bi matrix metalloproteinase ati inhibitor elastase.Awọn ẹkọ in vitro lori aabo ti ECM nipasẹ trifluoro-acetyl tripeptide 2 (TT2), kolaginni ti proteoglycan ninu awọn ibaraẹnisọrọ sẹẹli-matrix, ati ipa lori iṣelọpọ progerin ni awọn fibroblasts deede eniyan ti ogbo ni a ti mọ laipẹ bi olupilẹṣẹ ti cellular. imoran.Awọn abajade daba pe trifluoroacetyl tripeptide 2 ni ibiti o gbooro ti awọn ohun-ini egboogi-ti ogbo.Eyi dinku iṣelọpọ progerin, mu iṣelọpọ proteoglycan pọ si, ati dinku collagen, nitorinaa idinku awọn wrinkles ati imudarasi lile ara.Ni afikun, egboogi-wrinkling rẹ, adiye adiro-sisan ati awọn ipa mimu awọ ara ni a ṣe ayẹwo ni awọn ikẹkọ oju pipin in vitro meji.Trifluoroacetyl tripeptide 2 ti han lati ni awọn ipa ilọsiwaju lori awọn wrinkles, wiwọ, elasticity, ati sagging.

Le trifluoroacetyl tripeptide-2 idaduro ti ogbo?

Awọn ijinlẹ ti fihan pe isunmọ sẹẹli jẹ ibatan pẹkipẹki pẹlu Progerin.Pẹlu ti ogbo, presenilin n ṣajọpọ siwaju ati siwaju sii ninu ara, ti o yori si awọn abawọn iparun ati ibajẹ DNA, ti o yori si ibiti o ti dagba ti awọ ara.Trifluoroacetyl tripeptide-2 jẹ tripeptide ti nṣiṣe lọwọ ti Elafin, itọsẹ ti inhibitor elastase.O dinku iṣelọpọ Progerin ati ilọsiwaju laxity awọ ara, sagging ati wrinkles.

Ilana

1. Idilọwọ awọn kolaginni ti Progerin lati se idaduro cellular senescence.

2. Ṣe igbega iṣelọpọ syndecan ati gigun igbesi aye sẹẹli.

3. Idilọwọ awọn iṣẹ-ṣiṣe ti matrix metalloproteinases MMP1, MMP3 ati MMP9, din didenukole ti extracellular matrix awọn ọlọjẹ ati ki o bojuto wọn iyege.

4. Dena iṣẹ-ṣiṣe elastase, dinku ibajẹ elastin, ki o si jẹ ki awọ-ara ti o pọ sii ati rirọ.

Ohun elo

O dara fun gbogbo awọn iru ti egboogi-wrinkle ati egboogi-ti ogbo, firming titunṣe, egboogi-photoaging, ranse si-natal ati ranse si-oorun ara itoju, bbl O ti wa ni afikun ni ik ipele ti Kosimetik gbóògì